Pinched from Wikipedia...
Albert Hofmann (January 11, 1906 – April 29, 2008) was a Swiss scientist best known for having been the first to synthesize, ingest and learn of the psychedelic effects of lysergic acid diethylamide (LSD).
While synthesizing LSD in 1943, he accidentally absorbed a small quantity through his fingertips and serendipitously discovered its powerful effects.
He described what he felt as being:" ...affected by a remarkable restlessness, combined with a slight dizziness. At home I lay down and sank into a not unpleasant intoxicated-like condition, characterized by an extremely stimulated imagination. In a dreamlike state, with eyes closed (I found the daylight to be unpleasantly glaring), I perceived an uninterrupted stream of fantastic pictures, extraordinary shapes with intense, kaleidoscopic play of colors. After some two hours this condition faded away."
Three days later, in April 19th, 1943, Hofmann performed a self-experiment to determine the true effects of LSD, intentionally ingesting 250 micrograms of the substance, an amount he predicted to be a threshold dose (an actual threshold dose is 20 micrograms).
Less than an hour later, Hofmann experienced sudden and intense changes in perception. He asked his laboratory assistant to escort him home, and as use of vehicles was prohibited due to wartime restrictions, they had to make the journey on a bicycle. On the way, Hofmann’s condition rapidly deteriorated as he struggled with feelings of anxiety, alternatingly believing the next-door neighbor was a malevolent witch, that he was going insane, and the LSD had poisoned him. When the house doctor arrived, however, he could detect no physical abnormalities, save for a pair of incredibly dilated pupils.
Albert Hofmann LSD Trip - A Bicycle Trip - Basel 1943 from Anonymous Online Marketplaces on Vimeo.